Chronic Ethanol Feeding Alters miRNA Expression Dynamics During Liver Regeneration
نویسندگان
چکیده
منابع مشابه
Chronic ethanol feeding enhances miR-21 induction during liver regeneration while inhibiting proliferation in rats.
Liver regeneration is an important repair response to liver injury. Chronic ethanol consumption inhibits and delays liver regeneration in experimental animals. We studied the effects of chronic ethanol treatment on messenger RNA (mRNA) and microRNA (miRNA) expression profiles during the first 24 h after two-thirds partial hepatectomy (PHx) and found an increase in hepatic miR-21 expression in b...
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Effects of chronic ethanol feeding on the volume density of lysosomes, the rate of protein degradation and the amount of protein were studied in livers perfused in situ at 07:00, 11:00, 17:00 and 23:00 h. Ethanol was given to the rats in drinking water for either 3 or 8-10 weeks. During week 3 of treatment and onwards, the average daily consumption of ethanol was 12.3 +/- 0.3 g/kg body wt. Morp...
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When growth is stimulated in the normally quiescent adult rat liver by partial hepatectomy, steady state levels of messenger RNAs (mRNAs) for c-fos, c-myc, and p53 increase sequentially during the prereplicative phase which precedes DNA synthesis. Levels of c-fos mRNA are elevated at least 4-fold within 15 min after partial hepatectomy and decrease rapidly by 2 h; c-myc mRNA reaches maximal lev...
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The cytokines TNF and IL-6 play a critical role early in liver regeneration following partial hepatectomy (PH). Since IL-6 activates signal transducers and activators of transcription (STATs), we examined whether the suppressors of cytokine signaling (SOCS) may be involved in terminating IL-6 signaling. We show here that SOCS-3 mRNA is induced 40-fold 2 hours after surgery. SOCS-2 and CIS mRNA ...
متن کاملInterleukin-6 Mediates Angiotensinogen Gene Expression during Liver Regeneration
BACKGROUND Angiotensinogen is the precursor of angiotensin II, which is associated with ischemia-reperfusion injury. Angiotensin II reduces liver regeneration after hepatectomy and causes dysfunction and failure of reduced-size liver transplants. However, the regulation of angiotensinogen during liver regeneration is still unclear. AIMS To investigate the regulation of angiotensinogen during ...
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ژورنال
عنوان ژورنال: Alcoholism: Clinical and Experimental Research
سال: 2012
ISSN: 0145-6008
DOI: 10.1111/j.1530-0277.2012.01852.x